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Chondroitin and Dermatan Sulphates

Chondroitin and Dermatan Sulphate Polymers

A series of highly purified chondroitin sulphate and dermatan sulphate polymers that include the principal isomers found in mammalian tissues. The disaccharide compostion of our CS and DS polymers is shown below:

GAG-CSA01GAG-CSC01GAG-CSD01GAG-DS01
UA 1-3 GalNAc,4S62%20%37%75%
UA 1-3GalNAc,6S35%68%45%0%
UA 1-3 GalNAc3%
0%3%
UA2S-GalNAc6S0%10%18%0%
UA-GalNAc,4S,6S0%0%21%

These polysaccharides play essential structural and developmental roles in the ECM. Their specific molecular characteristics are often determined by sequences containing one or more rare disulphated disaccharide below:

D unit (GlcA,2S 1-3 GalNAc,6S) and E unit (GlcA 1-3 GalNAc,4S,6S). 

The polymers can be used to address how different levels and patterns of sulphation dictate the cellular and biochemical properties of the CS/DS family of GAGs

References:

Mizumoto, S., Yamada, S. & Sugahara, K. (2015) Molecular interactions between chondroitin–dermatan sulfate and growth factors/receptors/matrix proteins. (2105) Current Opinion in Structural Biology. 34, 35-42

Derbal, I., Lortat-Jacob, H. & Kwok, J. (2017) Chondroitin sulfates and their binding molecules in the central nervous system. Glycoconjugate J. 34, 363 - 376

Chrondroitin Sulphate AC Oligosaccharides 

Highly purified CS-A Oligosaccharides from dp4 to dp20

The oligosaccharides are prepared by the partial depolymerisation of Chondroitin Sulphate A (GAG-CSA01) by Chondroitinase AC then separated andpurified by high resolution gel filtration.   

General formula: *UA – (GalNAc,4S > 6S - GlcA)n=1-9 – GalNAc,4S>6S

*the uronic acid at the non-reducing end of the chain contains a C4-C5 double bond due to the endolytic action of Chondroitinase AC  

Chondroitin Sulphate D Oligosaccharides 

Highly purified CS-D Oligosaccharides from dp4 to dp20

The CSD Polymer (GAG-CSD01) used for preparation of the oligosaccharides contained 18% of the disulphated CSD disaccharide unit GlcA,2S – GalNAc,6S

General formula: ∆UA – (GalNAc,6S or 4S – GlcA +/- 2S)n – GalNAc,6S

Uronic acid (∆UA) at the non-reducing ends of the oligosaccharides has a C4-C5 double bond as a result of endolytic scission.

Dermatan Sulphate Oligosaccharides 

High-purity DS Oligosaccharides from dp4 to dp20

Prepared by controlled, partial depolymerisation of Dermatan Sulphate (GAG-DS01) by Chondroitinase B and separated by high-resolution gel filtration.   

General formula: *UA – (GalNAc,4S >4S,6S– IdoA)n=1-9 – GalNAc,4S

*the uronic acid at the non-reducing end of the chain contains a C4-C5 double bond due to the endolytic action of Chondroitinase AC

In the product list below dp = degree of polymerisation; dp4 (DSO04) is a tetrasaccharide, dp6 (DSO06) is a hexasaccharide etc

Please email [email protected] for further info or to place an order

Product Catalog No Qty £
  1. Chondroitin and Dermatan Sulphate Polymers
    Chondroitin Sulphate A GAG-CSA01 2mg
    121.00 Enquire Now
    Chondroitin Sulphate C GAG-CSC01 2mg
    135.00 Enquire Now
    Chondroitin Sulphate D GAG-CSD01 2mg
    135.00 Enquire Now
    Dermatan Sulphate GAG-DS01 2mg
    165.00 Enquire Now
  2. Chondroitin Sulphate AC Oligosaccharides
    Chondroitin Sulphate Oligosaccharide dp4 CSO04 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp6 CSO06 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp8 CSO08 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp10 CSO10 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp12 CSO12 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp14 CSO14 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp16 CSO16 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp18 CSO18 1mg
    185.00 Enquire Now
    Chondroitin Sulphate Oligosaccharide dp20 CSO20 1mg
    185.00 Enquire Now
  3. Chondroitin Sulphate D Oligosaccharides
    Chondroitin Sulphate D Oligosaccharide dp4 CSDO04 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp6 CSDO06 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp8 CSDO08 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp10 CSDO10 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp12 CSDO12 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp14 CSDO14 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp16 CSDO16 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp18 CSDO18 1mg
    185.00 Enquire Now
    Chondroitin Sulphate D Oligosaccharide dp20 CSDO20 1mg
    185.00 Enquire Now
  4. Dermatan sulphate oligosaccharides
    Dermatan Sulphate Oligosaccharide dp4 DSO04 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp6 DSO06 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp8 DSO08 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp10 DSO10 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp12 DSO12 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp14 DSO14 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp16 DSO16 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp18 DSO18 1mg
    185.00 Enquire Now
    Dermatan Sulphate Oligosaccharide dp20 DSO20 1mg
    185.00 Enquire Now

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