Chondroitin and Dermatan Sulphate Polymers
A series of highly purified chondroitin sulphate and dermatan sulphate polymers that include the principal isomers found in mammalian tissues. The disaccharide compostion of our CS and DS polymers is shown below:
GAG-CSA01 | GAG-CSC01 | GAG-CSD01 | GAG-DS01 | |
UA 1-3 GalNAc,4S | 62% | 20% | 37% | 75% |
UA 1-3GalNAc,6S | 35% | 68% | 45% | 0% |
UA 1-3 GalNAc | 3% | 0% | 3% | |
UA2S-GalNAc6S | 0% | 10% | 18% | 0% |
UA-GalNAc,4S,6S | 0% | 0% | 21% |
These polysaccharides play essential structural and developmental roles in the ECM. Their specific molecular characteristics are often determined by sequences containing one or more rare disulphated disaccharide below:
D unit (GlcA,2S 1-3 GalNAc,6S) and E unit (GlcA 1-3 GalNAc,4S,6S).
The polymers can be used to address how different levels and patterns of sulphation dictate the cellular and biochemical properties of the CS/DS family of GAGs
References:
Mizumoto, S., Yamada, S. & Sugahara, K. (2015) Molecular interactions between chondroitin–dermatan sulfate and growth factors/receptors/matrix proteins. (2105) Current Opinion in Structural Biology. 34, 35-42
Derbal, I., Lortat-Jacob, H. & Kwok, J. (2017) Chondroitin sulfates and their binding molecules in the central nervous system. Glycoconjugate J. 34, 363 - 376
Chrondroitin Sulphate AC Oligosaccharides
Highly purified CS-A Oligosaccharides from dp4 to dp20
The oligosaccharides are prepared by the partial depolymerisation of Chondroitin Sulphate A (GAG-CSA01) by Chondroitinase AC then separated andpurified by high resolution gel filtration.
General formula: *UA – (GalNAc,4S > 6S - GlcA)n=1-9 – GalNAc,4S>6S
*the uronic acid at the non-reducing end of the chain contains a C4-C5 double bond due to the endolytic action of Chondroitinase AC
Chondroitin Sulphate D Oligosaccharides
Highly purified CS-D Oligosaccharides from dp4 to dp20
The CSD Polymer (GAG-CSD01) used for preparation of the oligosaccharides contained 18% of the disulphated CSD disaccharide unit GlcA,2S – GalNAc,6S
General formula: ∆UA – (GalNAc,6S or 4S – GlcA +/- 2S)n – GalNAc,6S
Uronic acid (∆UA) at the non-reducing ends of the oligosaccharides has a C4-C5 double bond as a result of endolytic scission.
Dermatan Sulphate Oligosaccharides
High-purity DS Oligosaccharides from dp4 to dp20
Prepared by controlled, partial depolymerisation of Dermatan Sulphate (GAG-DS01) by Chondroitinase B and separated by high-resolution gel filtration.
General formula: *UA – (GalNAc,4S >4S,6S– IdoA)n=1-9 – GalNAc,4S
*the uronic acid at the non-reducing end of the chain contains a C4-C5 double bond due to the endolytic action of Chondroitinase AC
In the product list below dp = degree of polymerisation; dp4 (DSO04) is a tetrasaccharide, dp6 (DSO06) is a hexasaccharide etc
Please email [email protected] for further info or to place an order
Product | Catalog No | Qty | £ |
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Chondroitin Sulphate A | GAG-CSA01 | 2mg |
|
121.00 | Enquire Now |
Chondroitin Sulphate C | GAG-CSC01 | 2mg |
|
135.00 | Enquire Now |
Chondroitin Sulphate D | GAG-CSD01 | 2mg |
|
135.00 | Enquire Now |
Dermatan Sulphate | GAG-DS01 | 2mg |
|
165.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp4 | CSO04 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp6 | CSO06 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp8 | CSO08 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp10 | CSO10 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp12 | CSO12 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp14 | CSO14 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp16 | CSO16 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp18 | CSO18 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate Oligosaccharide dp20 | CSO20 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp4 | CSDO04 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp6 | CSDO06 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp8 | CSDO08 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp10 | CSDO10 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp12 | CSDO12 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp14 | CSDO14 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp16 | CSDO16 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp18 | CSDO18 | 1mg |
|
185.00 | Enquire Now |
Chondroitin Sulphate D Oligosaccharide dp20 | CSDO20 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp4 | DSO04 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp6 | DSO06 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp8 | DSO08 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp10 | DSO10 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp12 | DSO12 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp14 | DSO14 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp16 | DSO16 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp18 | DSO18 | 1mg |
|
185.00 | Enquire Now |
Dermatan Sulphate Oligosaccharide dp20 | DSO20 | 1mg |
|
185.00 | Enquire Now |
Produced by bacterial chondroitinase digestion of Chondroitin and Dermatan sulphate.
Prepared from high quality, mixed isomer shark cartilage Chondroitin Sulfate D (CSD) by partial GAG-endolyase scission.
Prepared from high quality, mixed isomer Chondroitin Sulfate by controlled GAG-endolyase scission..
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