1. Heparin Oligosaccharides   |  2. Heparin/Low-In-Calcium Heparin  |   3. Heparin Disaccharides  |
  4. Sulphated K5 Polysaccharides - semi-recombinant heparins  |  5. Selectively Desulfated Heparins |  
6. Hyaluronan Oligosaccharides and Disaccharide   |  7. K5 Heparan Lyase |  8. Heparan & Dermatan Sulphate   |  
9. Chondroitin/Dermatan Sulphate Disaccharides  |  
 | 10. Marine Glycosaminoglycans; Heparins, Heparans, Dermatans, Chondroitins  |
|  11. Heparinases and Chondroitinase B  |  12. Heparin/GAG Binding Plates

 

Marine Glycosaminoglycans; Heparins, Heparans Dermatans, and Chondroitins
A unique resource in the glycosaminoglycan lexicon

Marine organisms produce a rich variety of sulphated glycosaminoglycans with characteristic variations of sugar composition and sulphation patterns determined by the species of origin. The distinct molecular structures and biophysical properties of marine GAGS reflect the evolutionary adaptation and diversification of sulphated polysaccharides to complex and changing habitats. Some of the ancient properties of marine GAGS, which may have disappeared during terrestrial evolution, could offer valuable and unexpected insights in biomedical research.

We are working in collaboration with academic research institutes and with Glycomar in Oban, Scotland to put together a fascinating range of marine glycosaminoglycans that can be used in structure-function studies and tested in various applied biological systems, for example as biocompatible surface coatings in regenerative medicine and for supporting the growth and differentiation of embryonic and adult stem cells.

Marine GAGS are derived from organisms that have significant regenerative capacity. They may have interesting effects on the activities of many growth factors, morphogens etc (for example FGF, HGF/SF, VEGF, GDNF, Wg/Wnt) that are activated by Heparan Sulphate co-receptors.

 

Glycosaminoglycan
Catalogue Number
Quantity
 Price (GBP)
Dermatan Sulfate (DS-iD) 2-O, 6-O disulfated (ascidian)

main disaccharide (76% of total)
IdoUA (2-O-sulfate)1 – 3 GalNAc (6-O-sulfate)

minor disaccharide  (21% of total)
IdoUA 1 – 3 GalNAc (6-O-sulfate)

Mol. Wt. 18kDa
Single band on PAGE

M001 500ug £132
Dermatin Sulfate      

 

Glycosaminoglycan
Catalogue Number
Quantity
 Price (GBP)
Dermatan Sulfate (DS-iB)2-O, 4-O disulfated
(ascidian)

main disaccharide (66% of total)
IdoUA (2-O-sulfate)1 – 3 GalNAc (4-O-sulfate)
 
minor disaccharide (28% of total)
IdoUA 1 – 3 GalNAc (4-O-sulfate)  

Mol. Wt. 28kDa
Single band on PAGE 		M002 500ug £132
Dermatin Sulfate

This species of dermatan sulfate has anti-coagulant activity - it enhances inhibition of thrombin by heparin co-factor II

 

       
Glycosaminoglycan
Catalogue Number
Quantity
 Price (GBP)
Ascidian Heparin – low sulphated

Main disaccharides:
IdoUA (2-O-sulfated) 1 – 4  GlcNS (47% of total)

IdoUA (2-O-sulfated) 1 – 4 GlcNS (6-O-sulfated) 38% of total

Minor disaccharide
IdoUA (2-O-sulfated) 1 – 4 GlcNS (3-O-sulfated) 8% of total

Mol. Wt. 34kDa
Single band on PAGE 		M003 500ug £132

This invertebrate heparin has a relatively low content (38%) of the trisulfated disaccharide IdoUA (2-O-sulfated) 1-4 GlcNS (6-O-sulfated) that is the dominant disaccharide in mammalian heparins. The Ascidian heparin has anticoagulant properties due to the presence of 3-O-sulfated glucosamine residues. This distinct heparin species is likely to have some biological and physical properties that differ from mammalian heparins.

 

Glycosaminoglycan
Catalogue Number
Quantity
 Price (GBP)
Chondroitin Sulfate-Fucosylated (Eichinoderm - sea cucumber)

Main repeating unit:
GlcUA 1 – 3 GalNAc (6-O-sulfated) with Fucose (2-O and
4-O-sulfated) linked at the 3-position of GlcUA residues		 M004 500ug £132
Fucose Marine GAG
This highly sulfated (fucose-branched) Chondroitin Sulphate has anticoagulant activity (it potentiates thrombin inhibition by both antithrombin and heparin cofactor II) It has also been shown to enhance growth factor activities in angiogenesis models.

 

Marine Glycosaminoglycans from Glycomar

Glycosaminoglycan
Catalogue Number
Unit
Price
Scallop Heparan Sulfate (Pecten maximus)
C13 and H1 NMR indicate a low N-sulfated heparan sulfate.

Purity >90% by HPLC.
Mol Wt. 45kDa by HPLC-SEC.
Single band on PAGE.
Non-toxic by XTT assay.
Anticoagulant activity 30 IU/mg by APTT assay.
 GM01/1

GM01/5

GM01/10		 1mg

5mg

10mg		 £105

£310

£525
       
Whelk Heparan Sulfate (Neptunea antiqua)
C13 and H1 NMR indicate a low N-sulfated heparan sulfate

Purity >90% by HPLC.
Mol Wt 74kDa by HPLC-SEC
Single band on PAGE
Non-toxic by XTT assay
Anticoagulant activity 30 IU/mg by APTT assay		 GM02/1

GM02/5

GM02/10		 1mg

5mg

10mg		 £100

£300

£500
       
Crustacean Heparin (Nephrops norvegicus)
C13 and H1 NMR indicate a heparin/heparan sulfate type structure

Purity >90% by HPLC.
Mol Wt. 79kDa by HPLC-SEC
Single band on PAGE
Non-toxic by XTT assay
Anticoagulant activity 270 IU/mg by APTT assay

*Main disaccharides:
IdoUA (2-O-sulfate)1 – 4GlcNS   26% of total
IdoUA1 – 4GlcNS (6-O-sulfate) 27% of total
IdoUA (2-O-sulfate)1 – 4GlcNS (6-O-sulfate)  24% of total

*Minor disaccharide:
GlcUA/IdoUA (2-O-sulfate) 1 – 4GlcNAc(6-O-sulfate) 9% of total

*Disaccharides determined after heparinase depolymerisation - the hexuronic acid is shown as iduronic acid (IdoUA) based on NMR analysis of the intact chain. A minor amount of the hexuronic acid is present as glucuronic acid (GlcUA).		 GM03/1





GM03/5



GM03/10		 1mg





5mg




10mg		 £110





£320




£520 
       
Sea Squirt Dermatan Sulfate (Ascidiella aspersa)
C13 and H1 NMR indicate a dermatan sulfate type structure with presence of Fucose

Purity >90% by HPLC.
Mol Wt. 77kDa by HPLC-SEC
Two bands on PAGE
Non-toxic by XTT assay
No anticoagulant activity by APTT assay		 GM04/1

GM04/5

GM04/10		 1mg

5mg

10mg		 £120

£340

£545
       

Please contact info@iduron.co.uk for more information.

 

 

 


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